Your immune system normally helps the body by eliminating foreign threats, like infections. Cold Agglutinin Disease (CAD) is a form of autoimmune hemolytic anemia (AIHA), which means the immune system mistakenly attacks and destroys red blood cells which are required to help transport oxygen to your organs and tissues.
Those affected by CAD can range between 50-70 years of age but can be as young as 30.
While each person's experience of CAD may be different, some of the symptoms that have been reported include:
Symptoms of CAD may be caused by the clumping of red blood cells (agglutination) or the destruction of red blood cells (hemolysis). There are several symptoms that may be associated with hemolysis destroying healthy blood cells. When your body destroys red blood cells faster than it can make new ones, it becomes more difficult to get the oxygen the body needs for it to work properly. Too few red blood cells is called anemia, and can be the cause of some common symptoms associated with CAD, such as some of those listed above. Other symptoms, such as bluish or reddish discoloration of the skin and cold-induced circulatory symptoms are associated with agglutination.
When you have CAD, cold agglutinin antibodies attach to your healthy red blood cells. This leads to the activation of the classical complement pathway, which results in the destruction of the red blood cells. The pathway begins with the C1 protein binding to the red blood cells that are attached to the cold agglutinin antibodies, ultimately marking them for destruction. At the end of the pathway, the cells are destroyed, resulting in hemolysis.
The hemolysis caused by CAD lowers the amount of hemoglobin in your body. With fewer red blood cells in circulation, less oxygen is delivered to your organs and tissues. As a result, the continuous destruction of red blood cells caused by hemolysis may be responsible for certain symptoms of CAD.
On your journey with CAD, it's important to work with your healthcare team to stay informed and be your own advocate. We have some things that might help.
Whether you're taking ENJAYMO or interested in learning more, sign up to receive additional information, resources, and helpful tools to support you on your journey with Cold Agglutinin Disease.
Sign Up NowENJAYMO is a prescription medicine used to treat the breakdown of red blood cells (hemolysis) in adults with Cold Agglutinin Disease (CAD). It is not known if ENJAYMO is safe and effective in children.
ENJAYMO is a prescription medicine used to decrease the need for red blood cell transfusion due to the breakdown of red blood cells (hemolysis) in adults with cold agglutinin disease (CAD).
It is not known if ENJAYMO is safe and effective in children.
Do not receive ENJAYMO if you are allergic to sutimlimab-jome or any of the ingredients in ENJAYMO.
ENJAYMO can cause serious side effects, including:
Vaccinations may reduce the risk of these infections, but do not prevent all infections. Call your healthcare provider or get medical help right away if you get any new signs and symptoms of an infection, including:
The most common side effects of ENJAYMO include:
These are not all the possible side effects of ENJAYMO. Call your doctor for medical advice about side effects.
Before receiving ENJAYMO, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Please see Full Prescribing Information, including Medication Guide.
ENJAYMO is a prescription medicine used to decrease the need for red blood cell transfusion due to the breakdown of red blood cells (hemolysis) in adults with cold agglutinin disease (CAD).
It is not known if ENJAYMO is safe and effective in children.
ENJAYMO is a prescription medicine used to decrease the need for red blood cell transfusion due to the breakdown of red blood cells (hemolysis) in adults with cold agglutinin disease (CAD).
It is not known if ENJAYMO is safe and effective in children.
Do not receive ENJAYMO if you are allergic to sutimlimab-jome or any of the ingredients in ENJAYMO.
ENJAYMO can cause serious side effects, including:
Vaccinations may reduce the risk of these infections, but do not prevent all infections. Call your healthcare provider or get medical help right away if you get any new signs and symptoms of an infection, including:
The most common side effects of ENJAYMO include:
These are not all the possible side effects of ENJAYMO. Call your doctor for medical advice about side effects.
Before receiving ENJAYMO, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Please see Full Prescribing Information, including Medication Guide.